INDOMETHACIN

Course overview

INDOMETHACIN IS A NON-STEROIDAL ANTI-INFLAMMATORY (NSAID) DRUG WITH BROAD APPLICATIONS. IT INHIBITS THE SYNTHESIS OF PROSTAGLANDINS PRODUCED PRIMARILY BY CYCLOOXYGENASE ENZYMES WHICH ARE CRITICAL MEDIATORS OF INFLAMMATION, FEVER, AND PAIN. INDOMETHACIN IS FDA-APPROVED TO MANAGE ACUTE PAIN, RHEUMATOID ARTHRITIS, ANKYLOSING SPONDYLITIS, OSTEOARTHRITIS, BURSITIS, GOUTY ARTHRITIS, AND PATENT DUCTUS ARTERIOSUS. THIS ACTIVITY REVIEWS THE INDICATIONS, ACTION, AND CONTRAINDICATIONS OF INDOMETHACIN AS A VALUABLE AGENT. IN ADDITION, THIS ACTIVITY WILL HIGHLIGHT THE MECHANISM OF ACTION, ADVERSE EVENT PROFILE, AND OTHER KEY FACTORS (E.G., OFF-LABEL USES, DOSING, PHARMACODYNAMICS, PHARMACOKINETICS, MONITORING, AND RELEVANT INTERACTIONS) PERTINENT TO MEMBERS OF THE INTERPROFESSIONAL HEALTHCARE TEAM.