POLYGENIC HYPERCHOLESTEROLEMIA

Course overview

HYPERCHOLESTEROLEMIA CAUSES ATHEROSCLEROTIC VASCULAR DISEASE LEADING TO THE DEVELOPMENT OF CORONARY ARTERY DISEASE, TRANSIENT ISCHEMIC ATTACK, STROKE, AND PERIPHERAL ARTERY DISEASE. POLYGENIC HYPERCHOLESTEROLEMIA IS A FAMILIAL CONDITION WHERE THERE IS AN ELEVATION IN SERUM CHOLESTEROL LEVELS DUE TO MUTATION IN SEVERAL SMALL LDL RAISING ALLELES. THE MUTATION IS DETECTED USING 12 SINGLE NUCLEOTIDE POLYMORPHISMS (SNP) SCORE. POLYGENIC HYPERCHOLESTEROLEMIA IS ASYMPTOMATIC AND IS DETECTED DURING ROUTINE SCREENING. PRIMARY CARE PHYSICIANS AND CARDIOLOGISTS PLAY AN IMPORTANT ROLE IN EVALUATING AND TREATING PATIENTS TO REDUCE COMPLICATIONS OF THE DISEASE. THE ACTIVITY DESCRIBES THE EVALUATION AND TREATMENT OF POLYGENIC HYPERCHOLESTEROLEMIA BY PRIMARY CARE PHYSICIANS (PCPS) AND CARDIOLOGISTS.