ROTOR SYNDROME

Course overview

ROTOR SYNDROME, ALSO KNOWN AS ROTOR TYPE HYPERBILIRUBINEMIA, IS AN AUTOSOMAL RECESSIVE DISEASE AND A RARE CAUSE OF MIXED DIRECT (CONJUGATED) AND INDIRECT (UNCONJUGATED) HYPERBILIRUBINEMIA. THE DISEASE IS CHARACTERIZED BY NON-HEMOLYTIC JAUNDICE DUE TO CHRONIC ELEVATION OF PREDOMINANTLY CONJUGATED BILIRUBIN. THIS PHENOMENON RESULTS FROM IMPAIRED HEPATOCELLULAR STORAGE OF CONJUGATED BILIRUBIN THAT LEAKS INTO PLASMA, CAUSING HYPERBILIRUBINEMIA. ITS PRESENTING SYMPTOM IS JAUNDICE, BUT ROTOR SYNDROME IS A BENIGN, SELF-LIMITING DISORDER THAT DOES NOT REQUIRE TREATMENT. THIS ACTIVITY DESCRIBES THE PATHOPHYSIOLOGY AND PRESENTATION OF ROTOR SYNDROME AND HIGHLIGHTS THE ROLE OF THE INTERPROFESSIONAL TEAM IN ITS MANAGEMENT.