IRIDOCORNEAL ENDOTHELIAL SYNDROME

Course overview

IRIDOCORNEAL ENDOTHELIAL SYNDROME (ICE) IS A RARE CONDITION CHARACTERIZED BY THE INCREASED PROLIFERATION AND MIGRATION OF CORNEAL ENDOTHELIAL CELLS TO THE IRIS AND IRIDOCORNEAL ANGLE, LEADING TO SECONDARY ANGLE-CLOSURE GLAUCOMA, CORNEAL EDEMA, AND ATROPHY OF THE IRIS. ICE IS A GROUP OF DISORDERS WITH THREE CLINICALLY DISTINCT VARIANTS, INCLUDING ESSENTIAL IRIS ATROPHY (EIA), CHANDLER SYNDROME (CS), AND COGAN-REESE SYNDROME (CRS). IF LEFT UNTREATED, EACH VARIANT MAY PROGRESS TO BLINDNESS. HOWEVER, PROMPT DIAGNOSIS AND MULTIDISCIPLINARY MANAGEMENT CAN MITIGATE THIS CATASTROPHIC OUTCOME. THIS ACTIVITY REVIEWS THE PATHOPHYSIOLOGY, SIGNS AND SYMPTOMS, EVALUATION, DIFFERENTIAL DIAGNOSIS, AND MANAGEMENT OF ICE AND HIGHLIGHTS THE ROLE OF THE INTERPROFESSIONAL TEAM IN EVALUATING AND TREATING PATIENTS WITH THIS RARE CONDITION.