Lamotrigine: Label and Off-Label Uses

Course overview

Lamotrigine is an anticonvulsant and mood stabilizer used primarily in treating epilepsy and bipolar disorder, working by inhibiting voltage-gated sodium channels to stabilize neuronal activity and reduce excitatory neurotransmission. It requires slow dose titration due to the risk of severe skin reactions, including Stevens-Johnson Syndrome and toxic epidermal necrolysis. Healthcare providers must be vigilant about potential drug interactions and adverse effects and closely monitor patients for signs of toxicity and hypersensitivity reactions to optimize safety and efficacy.