A Review of Testosterone Replacement Therapy for the Healthcare Team

Course overview

Men can experience low testosterone levels for many reasons, including a natural decline occurring as they age. In this context, 'men' refers to individuals assigned male at birth (AMAB), though TRT is also used within the transgender and gender-diverse communities among those seeking masculinization. Some patients experience a more pronounced deficiency that can negatively affect their quality of life. Testosterone replacement therapy may be used to correct the symptoms of testosterone deficiency as well as maintain secondary sex characteristics. Testosterone replacement therapy is also a fundamental component of medical care for transgender men and other nonbinary individuals seeking masculinization, helping them achieve serum testosterone levels within the typical male reference range. There are benefits to testosterone replacement therapy, but these therapies are not without risk. Healthcare team members, including pharmacists and physicians, may overcome uncertainties and variations in diagnosis and management by being more knowledgeable about testosterone replacement therapy. Team members must be able to identify candidates for therapy, educate patients on proper use and risks, monitor adverse effects, and optimize therapeutic outcomes. This continuing education activity will explore the clinical applications of testosterone replacement therapy, including its benefits, risks, and considerations for safe and effective use, focusing on the roles of care team members.