Thiazide and Thiazide-Like Diuretics

Course overview

Thiazide and thiazide-like diuretics are one of four first-line drug classes recommended for treating primary hypertension in specific patient populations. Due to their proven efficacy in lowering blood pressure, they remain a preferred choice for hypertension management, even in patients with comorbid conditions such as diabetes. Although the frequency of adverse effects is not always specified in the prescribing information, clinicians should be aware that these diuretics can lower blood pressure, reduce intravascular volume, and potentially alter electrolyte levels, glucose, lipids, and uric acid. Consequently, monitoring for adverse effects such as electrolyte imbalances, hyperglycemia, hyperlipidemia, and exacerbation of conditions like gout is crucial in patients receiving thiazide therapy.