Nutrition 176

Course overview

Hour 1 *Compare the differences between acute and chronic inflammation. *Associate background inflammation with chiropractic treatment outcomes. *Discuss the aging trends in the U.S. population. *Summarize the role of aging on background inflammation. *Explain the differing outcomes of disc disease and radiculitis driven by inflammation. Hour 2 *Identify the mechanisms by which macrophages activate inflammation. *Discuss the historical trends in long chain fatty acid intake in relation to inflammation. *Explain the dependency on the COX 2 enzyme both in inflammatory up-regulation and in resolution. *Recognized dietary induced "meta-inflammation" and the dietary patterns that induce it. *Summarize the role of phytonutrients in limiting dietary induced inflammation. Hour 3 *Define immunosenescence and "inflammaging". *Summarize the role of autophagy in limiting inflammaging. *Summarize the role of apoptosis in eliminating senescent immune cells. *Examine the phytonutrients with senomorphic/pro-autophagy properties. *Examine the phytonutrients with senolytic/pro-apoptotic properties. Hour 4 *Describe the role of vagal nerve activation in regulating the transition to inflammatory resolution. *Examine the splenic cholinergic anti-inflammatory pathway. *Outline the mechanisms by which vagal activation increases specialized pro-resolving mediator (SPMs) production from omega-3 fatty acids. *Summarize the role of transcutaneous vagal nerve stimulation (tVNS) in the inflammatory to pro-resolving transition. *Contrast the inflammatory suppressing and pro-resolving treatment strategies.