Low Dose Naltrexone: Off-Label Applications in Autoimmune Disease Management

Course overview

This comprehensive continuing education course equips nurses with evidence-informed knowledge on Low Dose Naltrexone (LDN) and its emerging off-label applications in autoimmune and inflammatory disorders. Originally developed for the treatment of opioid and alcohol dependence, naltrexone at low doses has demonstrated promising immunomodulatory and anti-inflammatory properties. Through five in-depth chapters, learners will explore LDN's history, pharmacology, and mechanisms of action, as well as its potential role in conditions such as Hashimoto's thyroiditis, multiple sclerosis, inflammatory bowel disease, fibromyalgia, long COVID, cancer, and neurodegenerative diseases. The course emphasizes clinical application, patient selection, dosing strategies, safety considerations, and the nurse's role in patient education and monitoring. Ethical and legal considerations surrounding off-label prescribing are addressed, along with a review of the latest research findings and future directions for LDN in chronic disease management. Assessment questions at the end of each chapter reinforce learning and support competency in applying this knowledge to practice.