Nutrition 174 - 176

Course overview

Hour 1 *Understand basic concepts of health. *Identify the health spectrum. *Investigate the various facts associated with aging. *Investigate the various theories of aging. Hour 2 *Explain the basic principles of nutrigenomics, focusing on the interaction between nutrition, genetics, and health outcomes, with an emphasis on conditions like headaches. *Analyze how single nucleotide polymorphisms (SNPs) and other genetic variations impact nutrient metabolism and their potential role in triggering headaches, such as those linked to impaired methylation. *Examine the mechanisms by which a lack of essential nutrients (e.g., magnesium, B vitamins) contributes to headaches, and how nutrigenomics can inform targeted nutritional interventions. *Design tailored dietary strategies based on genetic testing results, addressing deficiencies or imbalances that may exacerbate headache conditions. *Assess the benefits and limitations of using nutrigenomic testing to guide clinical decision-making for headache management and prevention, highlighting the importance of personalized nutrition in improving patient outcomes. Hour 3 *Compare the differences between acute and chronic inflammation. *Associate background inflammation with chiropractic treatment outcomes. *Discuss the aging trends in the U.S. population. *Summarize the role of aging on background inflammation. *Explain the differing outcomes of disc disease and radiculitis driven by inflammation. Hour 4 *Identify the mechanisms by which macrophages activate inflammation. *Discuss the historical trends in long chain fatty acid intake in relation to inflammation. *Explain the dependency on the COX 2 enzyme both in inflammatory up-regulation and in resolution. *Recognized dietary induced "meta-inflammation" and the dietary patterns that induce it. *Summarize the role of phytonutrients in limiting dietary induced inflammation. Hour 5 *Define immunosenescence and "inflammaging". *Summarize the role of autophagy in limiting inflammaging. *Summarize the role of apoptosis in eliminating senescent immune cells. *Examine the phytonutrients with senomorphic/pro-autophagy properties. *Examine the phytonutrients with senolytic/pro-apoptotic properties. Hour 6 *Describe the role of vagal nerve activation in regulating the transition to inflammatory resolution. *Examine the splenic cholinergic anti-inflammatory pathway. *Outline the mechanisms by which vagal activation increases specialized pro-resolving mediator (SPMs) production from omega-3 fatty acids. *Summarize the role of transcutaneous vagal nerve stimulation (tVNS) in the inflammatory to pro-resolving transition. *Contrast the inflammatory suppressing and pro-resolving treatment strategies.