Understanding Hyperinflammatory Syndromes: From Recognition to Response

Course overview

This webinar offers a deep dive into the complex and evolving landscape of hyperinflammatory syndrome,, with a focus on understanding their underlying mechanisms, clinical presentations, and diagnostic challenges. Hyperinflammatory syndromes represent a spectrum of severe immune dysregulation, often characterized by excessive cytokine release and multi-organ involvement. These conditions can be life-threatening and are increasingly recognized across various clinical contexts. Audi Setiadi, MD, FRCPC, hematopathologist and investigator at BC Children's Hospital, will begin by defining hyperinflammatory syndromes and exploring their common features, including the role of cytokine dysregulation and immune system overactivation. A central focus will be on hemophagocytic lymphohistiocytosis (HLH) - a rare but critical condition - and cytokine release syndrome (CRS), which frequently occurs in the setting of CAR T-cell therapy and other immunotherapies.