The Gut-Brain Axis and its Relevance to Canine Cognitive Dysfunction

Course overview

There is increasing evidence that the gut microbiota is involved in the function and dysfunction of the brain. Dysbiosis, or an abnormal percentage of pathogenic gut bacteria, has been implicated in the pathogenesis of human Alzheimer's disease (AD). Canine cognitive dysfunction (CCD) is the dog version of human AD, having similar pathologic features. The gastrointestinal system is in constant contact with the brain via several conduits, collectively referred to as the gut-brain axis. There is evidence in rodent AD models and a few small human AD clinical trials, that correcting or improving dysbiosis can lead to improved cognitive function. This presentation will provide an overview of the gut-brain axis in health and disease. In addition, the potential role of fecal microbiota transplantation (FMT) in the treatment of CCD will be discussed, including case examples.