Pancreatic Histology: A Case-Based Approach

Course overview

The presentation addresses diagnostic challenges encountered in fine needle core biopsies of pancreatic mass lesions through a case-based approach. There will be a review of key histologic features essential for distinguishing pancreatic ductal adenocarcinoma (PDAC) from benign conditions, particularly chronic pancreatitis, using both morphological and immunohistochemical techniques. The presentation explores the diagnostic differential between neuroendocrine neoplasms, acinar cell carcinomas, and solid pseudopapillary lesions in the context of mixed pancreatic tumors, highlighting a few potential immunohistochemical pitfalls. Additionally, the presentation covers rare diagnoses that may not typically be considered in the setting of pancreatic mass lesions, as well as the uncommon occurrence of metastatic lesions to the pancreas. After this presentation, participants will be able to: Distinguish pancreatic ductal adenocarcinoma from benign pancreas on core needle biopsies Describe how to approach possible mixed pancreatic neoplasms Discuss diagnostic possibilities beyond the conventional spectrum of pancreatic masses Identify which malignancies are more likely to metastasize to the pancreas