Harnessing Ozone: Evidence-Based Applications

Course overview

See Mallorie Buscaglione, RN, in her presentation at HEAL 2026. Ozone therapy has been used in clinical medicine for more than a century and continues to gain attention in functional and integrative healthcare settings. In this lecture, Mallorie Buscaglione provides an overview of intravenous ozone therapy and its potential role in supporting oxygen utilization, immune modulation, and microcirculation. Participants will review the physiologic mechanisms underlying ozone therapy, including its influence on mitochondrial function, oxidative stress balance, and inflammatory signaling. The session also examines clinical considerations such as patient selection, contraindications, safety data, and expected responses such as Herxheimer reactions. In addition to the clinical science, this presentation discusses practical considerations for clinics evaluating ozone therapy, including treatment workflow, patient demand, and integration into an existing wellness or functional medicine practice. This session provides clinicians with a foundational understanding of IV ozone therapy so they can make informed decisions about whether and how to incorporate this modality into patient care.