Levorphanol as a Methadone Sparing Agent

Course overview

0202-9999-26-242-L08-P Most palliative care practitioners may be aware of the potential utility of levorphanol, and may have even used it in patients based on positive data in recent RCTs. However using it regularly can be difficult due to costs and access, with a relatively more familiar and cheaper alternative (methadone) available. Occasionally patients may not be able to continue on methadone therapy due to cardiotoxicity and alternatives need to be considered. Using rational polypharmacy may allow for a more practical way to help patients by taking advantage of the beneficial properties of levorphanol (limited QT prolongation), and methadone (cheap and accessible).