Functional Medicine and Nutrition Virtual Classroom 316 - Nutritional Genomics of Autoimmunity and Chronic Inflammation

Course overview

Identify the key features of Genomic Insight and Opus 23 Explorer as direct-to-provider tools for analyzing SNPs in autoimmunity and chronic inflammation. Differentiate between genes, SNPs, major and minor alleles, and explain how epigenetics influences gene expression through diet, lifestyle, and environment. Describe how HLA gene SNPs, including HLA-DQA1, DQA2, and DRB1, contribute to autoimmune risk and susceptibility in conditions like lupus, celiac, and psoriasis. Explain the roles of CD14, CD40, CD58, and interleukin genes IL-6, IL-8, and IL-10 in modulating immune and inflammatory responses. Apply targeted nutraceutical interventions to modulate NF-kB, TNF, and disease-specific genes involved in Crohn's disease and lupus. Evaluate genomic and therapeutic strategies for Crohn's, ulcerative colitis, and lupus, including NOD2, IRGM, IRF-5, and PTPN22 interventions. Analyze the genetic contributors to Hashimoto's, Graves' disease, and rheumatoid arthritis, including FoxP3, IL-1B, and HLA-DR4 mutations.