Mechanism of PCSK 9 Inhibitors and Clinical Utility

Course overview

Goals The goal of this article is to explore the mechanism of action of PCSK 9 inhibitors and their potential to improve cardiovascular outcomes in treatment of hypercholesterolemia Objectives 1. Assess consistency with labeled indications and treatment persistency for early adopters of PCSK-9 inhibitor pharmacotherapy. 2. Discuss how PCSK members are linked to other metabolic processes including regulation of lipid, glucose, and BA 3. Discuss the impact of PCSK9 inhibitors on plasma hs-CRP concentrations 4. Identify the four general reversible strategies which target PCSK9 in order to reduce its circulating levels 5. Identify the two permanent PCSK9 inhibition strategies 6. Discuss how LDLR negatively influences HDL cholesterol concentration