Hypocellular Bone Marrow: What's Next?

Course overview

Short description: Pathologic conditions characterized by peripheral cytopenia and bone marrow hypoplasia are not infrequent in community practice. The differential diagnosis usually includes many entities and the diagnostic work up may be very challenging. Increasing availability of molecular tests and emerging concepts of clonal hematopoiesis make the diagnostic investigation even more complex. The purpose of this presentation is to emphasize the importance of the diagnostic role of a pathologist, and delineate a practical step-by-step approach to bone marrow failure conditions including malignant, constitutional and idiopathic disorders. Objectives: 1. Identify the current definition of aplastic anemia and generate a comprehensive differential diagnosis. 2. Describe diagnostically relevant morphologic features. 3. Discuss currently available testing options and propose a practical diagnostic algorithm for bone marrow failure conditions.