ROTOR SYNDROME

Course overview

ROTORS SYNDROME, ALSO KNOWN AS ROTOR TYPE HYPERBILIRUBINEMIA, IS AN AUTOSOMAL RECESSIVE DISEASE AND A RARE CAUSE OF MIXED DIRECT (CONJUGATED) AND INDIRECT (UNCONJUGATED) HYPERBILIRUBINEMIA. THE DISEASE IS CHARACTERIZED BY NON-HEMOLYTIC JAUNDICE DUE TO CHRONIC ELEVATION OF PREDOMINANTLY CONJUGATED BILIRUBIN. THIS PHENOMENON IS A RESULT OF IMPAIRED HEPATOCELLULAR STORAGE OF CONJUGATED BILIRUBIN THAT LEAKS INTO PLASMA CAUSING HYPERBILIRUBINEMIA. ITS PRESENTING SYMPTOM IS JAUNDICE, BUT ROTOR SYNDROME IS A BENIGN, SELF-LIMITING DISORDER THAT DOES NOT REQUIRE TREATMENT. THIS ACTIVITY DESCRIBES THE PATHOPHYSIOLOGY AND PRESENTATION OF ROTOR SYNDROME AND HIGHLIGHTS THE ROLE OF THE INTERPROFESSIONAL TEAM IN ITS MANAGEMENT.