MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE

Course overview

MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE (MGUS) IS AN ASYMPTOMATIC PRENEOPLASTIC PLASMA CELL DISORDER THAT IS CHARACTERIZED BY SERUM M-PROTEIN LESS THAN 30G/L, BONE MARROW CLONAL PLASMA CELLS LESS THAN 10 PERCENT, ABSENCE OF PLASMA CELL MYELOMA-RELATED END-ORGAN DAMAGE (HYPERCALCEMIA, RENAL INSUFFICIENCY, ANEMIA, OR BONE LESIONS) AND ABSENCE OF B-CELL LYMPHOMA OR OTHER DISEASES KNOWN TO PRODUCE AN M-PROTEIN. MGUS IS GENERALLY CONSIDERED A PRENEOPLASTIC DISORDER THAT DOES NOT ALWAYS PROGRESS TO OVERT MALIGNANCY. THIS ACTIVITY DESCRIBES THE PATHOPHYSIOLOGY, PRESENTATION, AND DIAGNOSIS OF MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE AND HIGHLIGHTS THE ROLE OF THE INTERPROFESSIONAL TEAM IN ITS MANAGEMENT.