CHOLESTYRAMINE RESIN

Course overview

CHOLESTYRAMINE IS USED FOR THE TREATMENT OF PRIMARY HYPERCHOLESTEROLEMIA. THE REDUCTION IN LDL CHOLESTEROL BY THE RESIN IS DOSE-DEPENDENT. A DOSE OF 8 TO 12 GRAMS OF CHOLESTYRAMINE IS ASSOCIATED WITH 12% TO 18% REDUCTION IN LDL-CHOLESTEROL. IT ALSO REDUCES THE RISK OF CORONARY ARTERY DISEASE. CHOLESTYRAMINE CAN BE USED IN PATIENTS WITH BILE-ACID DIARRHEA OR CHOLERETIC ENTEROPATHY DUE TO LIMITED ILEAL DISEASE OR RESECTION. THIS ACTIVITY REVIEWS THE MECHANISM OF ACTION, ADVERSE EVENT PROFILE, TOXICITY, DOSING, PHARMACODYNAMICS, AND MONITORING OF CHOLESTYRAMINE THAT IS PERTINENT INFORMATION FOR MEMBERS OF THE INTERPROFESSIONAL TEAM WHEN LIPID LOWERING THERAPY IS INDICATED.