TERBINAFINE

Course overview

TERBINAFINE IS AN ANTIFUNGAL MEDICATION THAT WORKS THROUGH THE INHIBITION OF SQUALENE EPOXIDASE. IT HAS ACTIVITY AGAINST MOST DERMATOPHYTES, AND IT HAS APPROVAL FOR USE AS AN ORAL THERAPY FOR THE TREATMENT OF ONYCHOMYCOSIS. ALTHOUGH MOST SIDE EFFECTS ARE MILD AND SELF-LIMITED, SUCH AS HEADACHE AND GASTROINTESTINAL SYMPTOMS, TASTE DISTURBANCES (DYSGEUSIA) CAN RANGE FROM MILD TO SEVERE, AND RESULT IN WEIGHT LOSS AND HAS RARELY BEEN REPORTED PERMANENT. THIS ACTIVITY DESCRIBES THE INDICATIONS, MODE OF ACTION, AND SIDE EFFECTS OF TERBINAFINE AND HIGHLIGHTS THE ROLE OF THE INTERPROFESSIONAL TEAM IN ENSURING PROPER USAGE.