CILOSTAZOL

Course overview

CILOSTAZOL IS A QUINOLONE DERIVATIVE PRIMARILY USED FOR THE TREATMENT OF INTERMITTENT CLAUDICATION DUE TO PERIPHERAL VASCULAR DISEASE; THIS IS THE FDA APPROVED INDICATION. CILOSTAZOL ALSO HAS AN INDICATION AS SECONDARY PREVENTION FOR PATIENTS WITH A HISTORY OF TRANSIENT ISCHEMIC ATTACKS OR NON-CARDIOEMBOLIC ISCHAEMIC STROKE. CILOSTAZOL IMPROVES WALKING DISTANCE THROUGH THE PROMOTION OF VASODILATION AND ANTIPLATELET ACTIVITY WITH INHIBITION OF PHOSPHODIESTERASE III AND SUBSEQUENT INCREASES IN AVAILABLE CAMP. THIS ACTIVITY REVIEWS THE INDICATIONS, CONTRAINDICATIONS, AND USE OF CILOSTAZOL AND HIGHLIGHTS THE ROLE OF THE INTERPROFESSIONAL TEAM IN MONITORING THE ADVERSE EFFECTS OF THE DRUG.