LIDDLE SYNDROME

Course overview

RESISTANT HYPERTENSION IS A CONDITION IN WHICH BLOOD PRESSURE CONTINUES TO BE GREATER THAN 140/90 MM HG DESPITE COMPLIANCE WITH A REGIMEN OF 3 ANTIHYPERTENSIVE AGENTS INCLUDING A DIURETIC. LIDDLE SYNDROME IS ONE OF THE RARE CAUSES OF RESISTANT HYPERTENSION THAT PRESENTS IN EARLY CHILDHOOD. GRANT LIDDLE ET AL. FIRST EXPLAINED LIDDLE SYNDROME IN 1963. IT IS ALSO KNOWN AS PSEUDO ALDOSTERONISM. IT IS A RARE CAUSE OF SECONDARY HYPERTENSION DUE TO A GENETIC MUTATION, AFFECTING THE FUNCTION OF THE COLLECTING TUBULE SODIUM CHANNEL. THIS ACTIVITY REVIEWS THE ETIOLOGY, PRESENTATION, EVALUATION, AND MANAGEMENT OF LIDDLE SYNDROME AND REVIEWS THE ROLE OF THE INTERPROFESSIONAL TEAM IN EVALUATING, DIAGNOSING, AND MANAGING THE CONDITION.