PARANEOPLASTIC ENCEPHALOMYELITIS

Course overview

PARANEOPLASTIC ENCEPHALOMYELITIS IS A SUBTYPE OF PARANEOPLASTIC NEUROLOGICAL SYNDROMES. THIS GROUP OF NEUROLOGICAL DISORDERS IS ASSOCIATED WITH ANTIBODIES AGAINST INTRACELLULAR AND EXTRACELLULAR NEURONAL PROTEINS RELATED TO CANCER, INVOLVING FOCAL OR MULTIFOCAL INFLAMMATION OF THE BRAIN, SPINAL CORD, OR BOTH. THIS ARTICLE DESCRIBES THE PATHOPHYSIOLOGY, CLINICAL FEATURES, DIAGNOSTIC APPROACH, AND MANAGEMENT OF PARANEOPLASTIC ENCEPHALOMYELITIS AND HIGHLIGHTS THE ROLE OF THE INTERPROFESSIONAL TEAM IN EVALUATING AND TREATING PATIENTS TO AVOID HIGH MORBIDITY AND MORTALITY ASSOCIATED WITH THIS CONDITION.