SYSTEMIC LUPUS ERYTHEMATOSUS

Course overview

SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) IS A SYSTEMIC AUTOIMMUNE DISEASE WITH MULTISYSTEM INVOLVEMENT AND IS ASSOCIATED WITH SIGNIFICANT MORBIDITY AND MORTALITY. GENETIC, IMMUNOLOGICAL, ENDOCRINE, AND ENVIRONMENTAL FACTORS INFLUENCE THE LOSS OF IMMUNOLOGICAL TOLERANCE AGAINST SELF-ANTIGENS LEADING TO THE FORMATION OF PATHOGENIC AUTOANTIBODIES THAT CAUSE TISSUE DAMAGE THROUGH MULTIPLE MECHANISMS. THIS ACTIVITY REVIEWS THE EVALUATION AND MANAGEMENT OF SYSTEMIC LUPUS ERYTHEMATOSUS AND HIGHLIGHTS THE ROLE OF THE INTERPROFESSIONAL TEAM IN CARING FOR PATIENTS WITH THIS CONDITION.