ISONIAZID TOXICITY

Course overview

ISONIAZID (INH) IS A POTENT BACTERICIDAL ANTIBIOTIC USED IN THE TREATMENT OF TUBERCULOSIS. TREATMENT WITH INH THERAPY HAS A RISK OF TOXICITY, WHICH CAN BE ACUTE OR CHRONIC. ACUTE TOXICITY MANIFESTS AS NEUROLOGICAL SYMPTOMS. CONSUMPTION OF 2 G OF INH CAN PREDISPOSE A PATIENT TO ACUTE TOXICITY; WHILE CHRONIC TOXICITY USUALLY PRESENTS AS HEPATOTOXICITY AND PERIPHERAL NEUROPATHY. THIS ACTIVITY HIGHLIGHTS THE ROLE OF THE INTERPROFESSIONAL TEAM IN THE MANAGEMENT OF ISONIAZID TOXICITY.