HODGKIN LYMPHOMA

Course overview

HODGKIN LYMPHOMA (HL) IS A RARE MONOCLONAL LYMPHOID NEOPLASM CHARACTERIZED BY THE FOLLOWING FOUR FEATURES: HL USUALLY PRESENTS IN YOUNG ADULTS, COMMONLY ARISES IN CERVICAL LYMPH NODES, INVOLVES SCATTERED LARGE MONONUCLEAR HODGKIN AND MULTINUCLEATED REED-STERNBERG CELLS ON A BACKGROUND OF NON-NEOPLASTIC INFLAMMATORY CELLS, AND CHARACTERISTIC NEOPLASTIC CELLS ARE OFTEN SURROUNDED BY T LYMPHOCYTES. HODGKIN LYMPHOMA GENERALLY HAS AN EXCELLENT PROGNOSIS, THOUGH THIS DEPENDS ON SEVERAL FACTORS. HL IS DIVIDED INTO TWO DISTINCT CATEGORIES THAT DEMONSTRATE DIFFERENT PATHOLOGIC AND CLINICAL FEATURES: CLASSICAL HODGKIN LYMPHOMA AND NODULAR LYMPHOCYTE-PREDOMINANT HODGKIN LYMPHOMA (NLP-HL). CLASSICAL HODGKIN LYMPHOMA ACCOUNTS FOR APPROXIMATELY 95 PERCENT OF HL AND IS FURTHER SUBDIVIDED INTO FOUR SUBGROUPS: NODULAR SCLEROSIS (NSHL), LYMPHOCYTE-RICH (LRHL), MIXED CELLULARITY (MCHL), AND LYMPHOCYTE-DEPLETED (LDHL). THIS ACTIVITY ILLUSTRATES THE EVALUATION, TREATMENT, AND COMPLICATIONS OF HODGKIN LYMPHOMA AND THE IMPORTANCE OF AN INTERPROFESSIONAL TEAM APPROACH TO ITS MANAGEMENT.