CYCLOSPORINE

Course overview

CYCLOSPORINE IS AN IMMUNOSUPPRESSIVE AGENT USED TO TREAT ORGAN REJECTION POST-TRANSPLANT. IT ALSO HAS USE IN CERTAIN OTHER AUTOIMMUNE DISEASES, TREATMENT OF ORGAN REJECTION IN KIDNEY, LIVER, AND HEART ALLOGENEIC TRANSPLANTS, RHEUMATOID ARTHRITIS WHEN THE CONDITION HAS NOT ADEQUATELY RESPONDED TO METHOTREXATE. ALSO, IT IS A SECOND-LINE AGENT, FOR ALS, AND GRAFT VS. HOST DISEASE. IT ALSO HAS OTHER FDA AND NON-FDA-APPROVED INDICATIONS. THIS ACTIVITY REVIEWS THE MECHANISM OF ACTION, ADVERSE EVENT PROFILE, TOXICITY, DOSING, PHARMACODYNAMICS, AND MONITORING OF CYCLOSPORINE, PERTINENT FOR MEMBERS OF THE INTERPROFESSIONAL TEAM IN TREATING CONDITIONS WHERE CYCLOSPORINE IS INDICATED.