RENAL TRANSPLANTATION REJECTION

Course overview

VARIOUS FACTORS MERIT CONSIDERATION TO MATCH THE DONOR KIDNEY WITH THE RECIPIENT, AS THE DONOR KIDNEY ACT AS AN ALLOANTIGEN. IN GENERAL, WHEN TRANSPLANTING TISSUE OR CELLS FROM A GENETICALLY DIFFERENT DONOR TO THE GRAFT RECIPIENT, THE ALLOANTIGEN OF THE DONOR INDUCES AN IMMUNE RESPONSE IN THE RECIPIENT AGAINST THE GRAFT. THIS RESPONSE CAN DESTROY THE GRAFT IF NOT CONTROLLED. THE WHOLE PROCESS IS CALLED ALLOGRAFT REJECTION. THIS ACTIVITY DESCRIBES AND DEFINES THE TYPES OF REJECTIONS. IT ALSO DESCRIBES THE PATHOPHYSIOLOGY, HISTOPATHOLOGY, AND STAGING OF THE REJECTIONS VERY BRIEFLY. IT ALSO DESCRIBES THE RISK FACTORS, PROGNOSIS, AND DIFFERENTIAL DIAGNOSIS, ALONG WITH THE CLINICAL PRESENTATION, EVALUATION, AND TREATMENT.