Introduction to Clinical Cytogenetics: Lecture 2

Course overview

Short description: The Introduction to Clinical Cytogenetics lecture 2 will explore the many forms of chromosome structural rearrangements observed in cytogenetic studies, their nomenclature notation, and their relationship with health and disease in both the constitutional and cancer settings. Advanced concepts in oncology karyotype nomenclature will be presented to facilitate the recognition of tumor clonal diversity and complex karyotype interpretation. Objectives: 1. Describe the major classes of chromosome structural rearrangements in humans. 2. Identify neoplastic subclonal karyotypic complexity from the ISCN nomenclature. 3. Discuss the implications of balanced and unbalanced chromosome structural rearrangements in heredity and cancer.