NONKETOTIC HYPERGLYCINEMIA

Course overview

NONKETOTIC HYPERGLYCINEMIA IS A RARE, GENETIC, INBORN ERROR OF GLYCINE METABOLISM. DUE TO A MUTATION IN THE GLYCINE CLEAVAGE ENZYME SYSTEM, THE PATIENT IS UNABLE TO BREAKDOWN GLYCINE, RESULTING IN ITS ACCUMULATION THROUGHOUT THE BODY. THE BUILDUP OF GLYCINE PRIMARILY OCCURS WITHIN THE SPINAL CORD AND BRAIN; THUS, THE INITIAL CLINICAL MANIFESTATIONS AND LONG-TERM SEQUELAE FROM THIS CONDITION ARE OFTEN NEUROLOGICAL. THIS ACTIVITY REVIEWS THE EVALUATION AND MANAGEMENT OF NONKETOTIC HYPERGLYCINEMIA AND HIGHLIGHTS THE INTERPROFESSIONAL HEALTHCARE TEAM'S ROLE IN IMPROVING CARE FOR PATIENTS WITH THIS CONDITION.