COMMON VARIABLE IMMUNODEFICIENCY

Course overview

COMMON VARIABLE IMMUNODEFICIENCY IS A DISORDER CHARACTERIZED BY DEFECTIVE B CELL FUNCTION LEADING TO IMPAIRED IMMUNOGLOBULIN PRODUCTION. IT CAN PRESENT WITH HETEROGENEOUS CLINICAL MANIFESTATIONS SUCH AS RECURRENT INFECTIONS, CHRONIC LUNG DISEASE, AUTOIMMUNE DISORDERS, GASTROINTESTINAL DISEASE, OR INCREASED RISK OF MALIGNANCY. WHILE SOME RESEARCHERS HAVE IDENTIFIED SOME GENETIC DEFECT, THE FUNDAMENTAL CAUSE OF CVID HAS BEEN CHALLENGING TO DETERMINE.