BRUTON AGAMMAGLOBULINEMIA

Course overview

BRUTON AGAMMAGLOBULINEMIA, ALSO KNOWN AS X-LINKED AGAMMAGLOBULINEMIA (XLA) OR BRUTON'S AGAMMAGLOBULINEMIA, IS AN INHERITED IMMUNODEFICIENCY DISORDER. IT IS CHARACTERIZED BY THE ABSENCE OF MATURE B CELLS WHICH IN TURN LEADS TO SEVERE ANTIBODY DEFICIENCY AND RECURRENT INFECTIONS. IT CAN MANIFEST IN AN INFANT AS SOON AS THE PROTECTIVE EFFECT OF MATERNAL IMMUNOGLOBULINS WANES AT AROUND SIX MONTHS OF AGE. THIS ACTIVITY REVIEWS BRUTON AGAMMAGLOBULINEMIA AND HIGHLIGHTS THE ROLE OF THE INTERPROFESSIONAL TEAM IN ITS EVALUATION AND MANAGEMENT.