NEUROLOGY 208D2

Course overview

*Define Neurodegeneration. *Identify some of the core mechanisms of Neurodegeneration. *Define and discuss oxidative stress and damage of neurons. *List most common neurological illnesses thought to be due to long-term Neurodegeneration. *Cite specific biochemical pathways to target therapeutically to slow down or reverse Neurodegeneration. *Itemize common clinical findings in Parkinson's disease, Alzheimer's disease, and multiple sclerosis. *List the mechanisms involved in the neurodegenerative process. *Define free radicals, articulate the issue with free radicals and describe their role in the neurodegenerative process. *Discuss the role of glial cells in regard to Neurodegeneration. *Itemize ways to increase the Nrf2 pathway. *Discuss glutathione and list specific methods to increase glutathione levels. *List dangers found in regard to genetically modified foods. *Compare and contrast normal mitochondrial structure and function with dysfunctional mitochondria with attention to free radical damage to my no conjugal proteins and mitochondrial DNA. *Discuss the therapeutic role of essential fatty acids (EFA's), Acetyl-L-Carnitine, and coenzyme Q-10. *List and discuss methods for laboratory evaluation of systemic inflammation. *Itemize issues associated with the "leaky gut" syndrome, including aspects of inflammation, relation to diabetes, and Zonulin.