(HS Langlois 078431 2022) Novel and Not So Novel Anticoagulants: Mechanism of Action, Indications for Clinical Use and...

Course overview

Options for anticoagulation have been expanding steadily over the past few decades, providing a greater number of agents for prevention and management of thromboembolic disease. In addition to heparins and vitamin K antagonists, anticoagulants that directly target the enzymatic activity of thrombin and factor Xa have been developed. Appropriate use of these agents requires knowledge of their individual characteristics, risks, and benefits. In this recording, we highlight with clinical case studies and pharmacodynamic data the practical aspects of the use of direct thrombin inhibitors (oral and parenteral) and oral direct factor Xa inhibitors, along with other anticoagulants in development (medications which target the active form of factor XI and monoclonal antibody Blocking factor XI). Indications and efficacy of anticoagulants in specific clinical settings and under clinical conditions are presented. Moreover, management of bleeding and perioperative management of patients receiving direct thrombin inhibitors and direct factor Xa inhibitors will also be discussed.