Zolpidem Treatment for Primary Insomnia and for Chronic Comorbid Insomnia

Course overview

Zolpidem is a sedative-hypnotic medication that is indicated for the short-term treatment of insomnia. It induces sleep by binding to benzodiazepine-1 receptors that are associated with GABA receptors. It is available as immediate and extended-release tablets, sublingual tablets, and as an oral spray. Treatment with zolpidem should be as short as possible. The most common adverse effects of zolpidem are drowsiness, headache, and dizziness. Zolpidem is also associated with the risk for health-related concerns, including sleep disorders and substance use disorders, especially with longer-term use. Health clinicians should educate patients on the issues related to side effects and drug interactions of zolpidem.