POLYGLANDULAR AUTOIMMUNE SYNDROME TYPE II

Course overview

POLYGLANDULAR AUTOIMMUNE SYNDROME TYPE 2 (PAS-2) IS AN AUTOIMMUNE SYNDROME WHICH LEADS TO LYMPHOCYTIC INFILTRATION CAUSING ORGAN-SPECIFIC DAMAGE. PAS-2 IS DIAGNOSED WHEN AT LEAST 2 OUT OF 3 OF THE FOLLOWING ARE PRESENT: PRIMARY ADRENAL INSUFFICIENCY (ADDISON DISEASE), AUTOIMMUNE THYROID DISEASE-CAUSING GRAVE'S DISEASE OR HYPOTHYROIDISM, AND TYPE 1 DIABETES MELLITUS (T1DM). CARPENTER SYNDROME IS A TYPE OF PAS-2 THAT INCLUDES THE TRIAD OF ADDISON DISEASE, AUTOIMMUNE THYROID DISEASE, AND T1DM. THIS ACTIVITY REVIEWS THE DIAGNOSIS AND MANAGEMENT OF THE CARPENTER SYNDROME VARIANT OF PAS-2 AND HIGHLIGHTS THE ROLE OF THE INTERPROFESSIONAL TEAM IN THE EARLY DETECTION AND MANAGEMENT OF THIS CONDITION.