DAPTOMYCIN

Course overview

DAPTOMYCIN IS A CYCLIC LIPOPEPTIDE ANTIBIOTIC DERIVED FROM THE ORGANISM STREPTOMYCES ROSEOSPORUS. DAPTOMYCIN IS USED TO TREAT VARIOUS BACTERIAL INFECTIONS CAUSED BY GRAM-POSITIVE BACTERIA, INCLUDING METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) AND VANCOMYCIN-RESISTANT ENTEROCOCCI (VRE). DAPTOMYCIN HAS NUMEROUS FDA-APPROVED AND OFF-LABEL CLINICAL USES. THIS ACTIVITY REVIEWS THE MECHANISM OF ACTION, ADVERSE EVENT PROFILE, TOXICITY, DOSING, PHARMACODYNAMICS, AND MONITORING OF DAPTOMYCIN, PERTINENT FOR INTERPROFESSIONAL TEAM MEMBERS IN TREATING CONDITIONS WHERE DAPTOMYCIN IS APPROPRIATE.