ANAPLASTIC LARGE CELL LYMPHOMA

Course overview

ANAPLASTIC LYMPHOMA KINASE POSITIVE (ALK+) ANAPLASTIC LARGE CELL LYMPHOMA (ALCL), IS A T-CELL LYMPHOMA CHARACTERIZED BY LARGE, PLEOMORPHIC LYMPHOID CELLS WITH ABUNDANT CYTOPLASM AND HORSESHOE-SHAPED NUCLEI, POSITIVE FOR CD30. ALK+ ALCL HAS ASSOCIATED RECURRENT T(2;5) FUSION TRANSLOCATION INVOLVING THE ALK GENE AND NUCLEOPHOSMIN (NPM1) GENE. THIS CME ACTIVITY OUTLINES THE EVALUATION AND MANAGEMENT OF ALK+ ALCL WHILE HIGHLIGHTING THE ROLE OF THE INTERDISCIPLINARY HEALTHCARE TEAM IN THE MANAGEMENT OF THIS CONDITION.